Maybe it's just me but I don't really have the same interest in a ES 6 or Fallout 5 due to the trend and direction they'll likely go with. Customizable single player world was really the main draw to me. However I think it's highly likely they'll want to monetize modding from the onset and make it more multiplayer focused.
Call me naive, but I think Todd Howard has still got the creative magic. But I'm afraid of the suits who will try to force a multiplayer world. TES:V was a huge success as a single player game and still going strong even today. So how much clout does Howard have with Zenimax exactly? Can he do the movie director thing and threaten to walk away if he isn't given full creative control?