Can't really say; they're each targeted at different markets. In general, I'd stay away from front panel anything, as that involves running analog lines through the noise-center of the PC. Option of last resort really, unless the breakout box has its own power and DACs, which at that point it is its own sound card. Other side is what you'll be plugging into it. A low-impedance gaming headset is no big deal, but a high-impedance set of cans like some 250Ω Beyerdynamic DT770 bass canons or some 600Ω DT990 cans will want for more power to really fill out the frequency response at respectable volume levels. So, what are you intending to power with the sound card, and what are you intending to play?