Does anyone else have a weird bug where play/pause on their keyboard doesn't work unless WMP, Zune, or whatever you are using is not minimized ? I'm using Vista Ultimate 64-Bit with a Wireless Desktop Elite keyboard
Do you have the latest drivers for the keyboard/mouse? Make sure you do, and make sure you are assigning the keys properly in the software config for the keyboard.
I'm running a Microsoft NEK4000 keyboard, and I've assigned the palm area Back/Forward buttons to previous track/next track. They work flawlessly, but I'm using it in Winamp. I also use what's called "Winamp Controllers" to properly assign the shortcut keys on my keyboard. They work perfectly.