Depends what your needs are? The main differences are:
- software/UEFI
- I/O/port config
- possibly extreme overclocking
I have never owned one of the sabertooth motherboards and it seems like the thermal armor may not really be that necessary.
I have been cruising the forums reading as much as possible about the Supreme FX IV audio chip on the Asus MVF. So far, the feedback on the audio has been positive. There are many converts out there, guys that swore by discrete audio and had no confidence to make the switch. Seen some guys even still clinging to their old Audigy II cards...which is ridiculous really. The ones that took the time to try it and hear it for themselves have given up the add in sound card and been happy with the MVF's onboard.
I have an older AMD 790 chipset board and I cannot tell between my X-Fi Gamer and that. So I ditched it 2 years ago.
I would say, unless you are truly an extremely picky, anal retentive audiophile...you will not notice.
Thanks for the feedback about the audio card / on-board sound. Since I have the Xonar I would just have to see if the same though regarding no being able to hear the difference is the same. I just game with a 2.1 sound system or headphones right now.