Theres the recording itself (amount of detail lost in compression may or may not be a lot), there the Codecs and decoding hardware (to convert to analog) and then theres the reproduction of sound, speakers headphones etc. And maybe an amplifier as well. Then there is also the listeners ears.
If anyone one of these has a weak point, then you may not get the full benefit of FLAC.
If your not clipping the music signal in the audiable spectrum then the compression does not matter, if your codec etc is not processing the FLAC correctly then you jsut lost your benefit. High end speakers should be able to better reproduce sound, but they may not excel is reproducing whatever was lost during compression. Then your ears might not be able to pickup the majority of material being clipped by all of the previous.
Most music I prefer 190 or above. If it's particularly details 320 and above. If it's my favorite Band I'll go FLAC, but one disadvantage (other than space) is that most devices still do not support FLAC. So you have to make an MP3 copy anyways...It's easy to say a 1TB hard drive is cheap but I don't have 1TB available on my phone or car or laptop etc.
media monkey pro and I think also J River media center convert Flac to MP3 on the fly when syncing to mobile device.