Except for FOV and vsync I haven't gotten frisky with my .ini files but it could be a coincidence but since I've gone back to an old habit from especially Oblivion of deliberately NOT loading from auto saves and avoiding quick saves like the plague, I haven't had ONE CTD or problem whatsoever.
Ive been using the quick saves and havent had a single crash or problem yet, only added the fov fix and mouse fix to the ini so far though.