Two 22's - spoken from experience. I take my 2x 22 over my 1x37 anyday. But then, much of what i do is multitasking. Sometimes its nice to have only one monitor to focus on when gaming, but if youre gaming and want to keep open windows on the other screen to do, say, HWMonitor, or watch a download in the background, nothing does the trick better.
I have a 24 and a 22. If I was playing games/watching TV the 24" is a winner. But when it comes time to do work, I would probably get an aneurysm if I couldn't have the second 22" monitor. If this is for doing work, the 2 monitors is the only answer. Right now, I'm waiting for a sale so I can get another 22" cheap and have three screens.