Right, if you buy a dual GPU Nvidia card you are running SLI, presumably each chip is using x8 lanes. However, if you set up SLI yourself I think you have to be using an "SLI-cerfitied" board from this list: http://www.geforce.com/hardware/technology/sli/motherboards Notice how there aren't any mini-ITX boards there... As for crossfire, these days you don't even have to buy a bridge anymore, everything operates over the PCI-E bus and any motherboard will work. Am I right about this? I'm hoping SLI is possible without needing an approved board... EDIT: Here's some funky way of getting SLI working on a non-SLI certified motherboard: http://www.techpowerup.com/forums/threads/hypersli-enabling-sli-on-non-sli-motherboards.153046/ Seems pretty funky. Is this really necessary?? Or is this obsolete info?