Edit edit: OK maybe not horrible, but not great.You may want to check your manual, but it appears that it will work ok:
http://www.asus.com/Motherboards/P8Z68VGEN3/#specifications
"*2: The PCIe x16_3 slot shares bandwidth with PCIe x1_1 slot, PCIe x1_2 slot, USB3_34 and eSATA. The PCIe x16_3 default setting is in x1 mode."
EDIT/Note to the guy above talking about the G35's instead: Don't do it! I own the G35's and G930's and they have, in my esteemed opinion, horrible bass. I do like the convenience of the attached microphone, but they in no way compare to a good set of headphones and a sound card.
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