A New Painkiller Promises Relief Without Addiction

DooKey

DooKey

[H]F Junkie
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Everyone knows by now that the U.S. is experiencing a huge opioid addiction problem and it gets worse every day. As a matter of fact, approximately 91 people die everyday from overdoses of painkillers. A new study of an opioid compound named AT-121 is showing non-addictive properties in simian testing. Monkeys were found to get addicted to normal opioids just like humans and then they were offered this painkiller and they only used the compound when they needed it. This compound works by attaching to the pain receptors like normal opioids, but it also attaches to receptors that mediate behaviors governed by emotions and instincts. This appears to be what stops the euphoric feelings that occur with normal opioids. Another great feature of this compound is it appears to be much stronger than morphine without the ill effects of respiratory problems. However, this isn't ready for humans and needs more testing before it hits the market. Regardless, this is good news and I hope it hits the market sooner than later.


At first glance, the fact that the study focused on monkeys would seem to be a factor against AT-121’s favor. This is definitely true in the sense that humans could react quite differently to the compound and its effects, and it should not be assumed AT-121 is anywhere near ready for people. But Roth emphasizes that since the two species share quite a bit of the same physiology, “the potential translation to humans has a greater potential for success.”
 
yay! hopefully its not bs and it comes through. would love something for pain that is not addictive (other than MJ which is a long shot in wisconsin)
 
Oh great, now who's Kruger going to fix up!?
kruger.jpg
 
So stupid question - But will this help with the opiate crisis for someone that is already addicted? If they are addicted to the euphoric sense and this doesn't fulfill that for them then one would think this may not help addicts recover?

Or will this strictly only potentially PREVENT addiction?


Either way sounds very promising.
 
Cyraxx said:
So stupid question - But will this help with the opiate crisis for someone that is already addicted? If they are addicted to the euphoric sense and this doesn't fulfill that for them then one would think this may not help addicts recover?

Or will this strictly only potentially PREVENT addiction?


Either way sounds very promising.
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I would assume #2. Something to prescribe that prevents the issue in the first place.
 
"Pain don't hurt..." -- Dalton, Road House

Armenius said:
I saw the thread title and thought we were talking about a new Painkiller game. Now leaving, gutted and and still looking for a fix.
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Heaven's Got A Hitman

 
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I can't stand how intoxicating pain killers are. Don't get me wrong, I'm not above getting a buzz. I just dislike the sort that comes with pain killers. If this doeszn't give you a buzz I'd probably be more likely to use pain killers. Maybe.
 
S-F said:
I can't stand how intoxicating pain killers are. Don't get me wrong, I'm not above getting a buzz. I just dislike the sort that comes with pain killers. If this doeszn't give you a buzz I'd probably be more likely to use pain killers. Maybe.
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I personally hate anything that affects the way my brain functions, so I always turn down opiates when they're offered to me. I'm amazed at how easily they're prescribed, though. Don't want to call anyone out, but fairly recently I cut a chunk of one of my fingernails out. I said the pain was about a 3 or 4, and they wrote me a script for oxycodone :eek:. Told them I didn't want it, said they'll push it to my pharmacist anyway in case I change my mind.
 
I can't take prescription pain meds, they are a mess. I just take high dose ibuprophen. It's safe someone my size to take up to 800mg 3 times a day when my body flairs up from old age and my rigorous exercise...

This is very promising.
 
Good thing early testing on monkeys always translates to repeatable safe results on humans so they can pre-hype a drug no where near it's final stages for use. :p

That never backfires countless times on AIDS drugs, Cancer drugs, etc. :p
 
Cyraxx said:
So stupid question - But will this help with the opiate crisis for someone that is already addicted? If they are addicted to the euphoric sense and this doesn't fulfill that for them then one would think this may not help addicts recover?

Or will this strictly only potentially PREVENT addiction?


Either way sounds very promising.
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Unlikely. Brain chemistry has already been altered. Hence the creation of methadone.

Undoing long term neural connections is a major pain in the ass. But if we can figure out ways to do this we can cure a number of diseases including Addiction, Anxiety, and PTSD
 
Commander Shepard said:
Who needs a new pill when you can ease your pain by taking a few hits from this...

View attachment 100463

http://www.latimes.com/nation/la-na-largest-bong-vegas-20180831-story.html
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Long term THC use is now shown to physically alter pathways in the brain making them "narrower" primarily in the connections to the frontal cortex which is our "inhibitions control", "reasoning" and "motivation" Brain function can be altered for long past 24 Hrs of THC introduction.

This is all based on MRI studies that have been becoming available in the last couple of years. The effects of which are more prevalent to those who use THC whom are < 25 when the brain is still developing. Make no mistake, THC is NOT a safe drug, although it does have medicinal benefits in other areas (pain management, hunger for chemo patients, glaucoma, and seizure control are a few examples.) . Not only this, but [edit]WEED[/edit] contains up to 50x's more tar than a standard cigarette. This is one of the primary causes of lung cancer. In fact weed introduces a LOT of carcinogens to your lungs/stomach including Arsenic, and Cyanide. The total number of carcinogenic compounds is in excess of 50. It's prescription benefits needs to be weighed against the risk and side effects. Although if given a choice, pure THC that is refined is a better choice over standard weed.
 
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As one of the first to go vaporization many years ago I keep a pretty high THC level at all times. I have not used a painkiller in several decades. ;)
 
DigitalGriffin said:
Long term THC use is now shown to physically alter pathways in the brain making them "narrower" primarily in the connections to the frontal cortex which is our "inhibitions control", "reasoning" and "motivation" Brain function can be altered for long past 24 Hrs of THC introduction.

This is all based on MRI studies that have been becoming available in the last couple of years. The effects of which are more prevalent to those who use THC whom are < 25 when the brain is still developing. Make no mistake, THC is NOT a safe drug, although it does have medicinal benefits in other areas (pain management, hunger for chemo patients, glaucoma, and seizure control are a few examples.) . Not only this, but THC contains up to 50x's more tar than a standard cigarette. This is one of the primary causes of lung cancer. In fact weed introduces a LOT of carcinogens to your lungs/stomach including Arsenic, and Cyanide. The total number of carcinogenic compounds is in excess of 50. It's prescription benefits needs to be weighed against the risk and side effects. Although if given a choice, pure THC that is refined is a better choice over standard weed.
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Lemme guess... you're the dork who sucks all the fun outta the room whenever there's a party.
 
PenGunn said:
As one of the first to go vaporization many years ago I keep a pretty high THC level at all times. I have not used a painkiller in several decades. ;)
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Used to smoke back in high school. Would hit a few times after when I had really bad sunburns. Instant pain relief, made it tingly and fun feeling.
 
PenGunn said:
As one of the first to go vaporization many years ago I keep a pretty high THC level at all times. I have not used a painkiller in several decades. ;)
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Care to volunteer for a cognitive and psychological processing test while attached to a MRI. It's for science. :D
 
Commander Shepard said:
Lemme guess... you're the dork who sucks all the fun outta the room whenever there's a party.
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Yes. And I was hall monitor too.

I let people be people. Be my guest and smoke away if it makes you happy. I have two rules though:

1. Don't dismiss the dangers to justify your actions. Go in knowing the risk, and accept responsibility for them. That also means don't expect other people to clean up your mess if you screw up.
2. Don't put yourself in a situation that can harm others. (ie: Driving or working while stoned)
 
DigitalGriffin said:
Yes. And I was hall monitor too.

I let people be people. Be my guest and smoke away if it makes you happy. I have two rules though:

1. Don't dismiss the dangers to justify your actions. Go in knowing the risk, and accept responsibility for them
2. Don't put yourself in a situation that can harm others. (ie: Driving or working while stoned)
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Sounds perfectly reasonable
 
I'll believe it when I see it. They claimed tramadol was less addictive and it turned out that not only is it just as addictive as other opioids, the addiction happens way faster. After a surgery I was on that crap for only eight days and withdrew from it like I had been on it for a year, and everybody I know that has been on it has had the same result.
 
NukeDukem said:
Tar is a byproduct of cellulose combustion, THC does not "contain" tar. Ever heard of vaporization?
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THC doesn't contain tar because it's THC, NOT TAR. This is why I recommend refined THC.

https://www.snopes.com/fact-check/dirty-dope/

Here they cite 4'x deposits. In the lab I've personally seen samples where it's 50x's under the worst cases. (Using HPGC analysis) My former employer presented papers on analysis of pot to ACS to show the strengths of our hardware in sensitivity compared to our competitors. Our science is neutral as we just want to show performance, not the benefits and cons of pot use.

The fact there is less cancer rates associated with pot is because people smoke it less. (It is after all more expensive and brain altering. You can't go around high all day, but you can smoke all day.) The fact remains you are introducing carcinogens to your lungs at a high rate but with less frequency.
 
bobdabilder said:
Did i read that 91 people a day die from opioid od? Well 101 people die per day in car crashes. When do we stop selling addictive cars?.......bastards.
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*Actually according to the CDC, 2017 has 48K overdose deaths attributed to opioids, with the number expected to rise. That's actually 131 a day.

In Canada, 11 a day die from opioids.

And just to preempt source requests:
https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm
https://www.canada.ca/en/public-hea...opioid-related-deaths-released-june-2018.html

*edit: this figure does not include synthetic opioids
 
bobdabilder said:
Did i read that 91 people a day die from opioid od? Well 101 people die per day in car crashes. When do we stop selling addictive cars?.......bastards.
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Not only the user is affected. It affects the community as a whole through increased crime and increased dependence on social programs. It also leads to increased disease (dirty needles) and collateral damage to friends/family. If you don't believe me, let me introduce you to the addicted baby ward where they do nothing but cry because of withdrawal.
 
DigitalGriffin said:
THC doesn't contain tar because it's THC, NOT TAR. This is why I recommend refined THC.
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Yet I just quoted you saying THC contains up to 50x more tar than a standard cigarette, which made no sense. Maybe you misspoke.

Most people I know who use pot VAPORIZE it, which eliminates tar and 95+% of all carcinogens. Personally I haven't smoked anything since 2005. Nasty and archaic method to consume anything. No need to demonize a non-toxic substance (THC) by conflating it with tar produced via combustion.
 
NukeDukem said:
Yet I just quoted you saying THC contains up to 50x more tar than a standard cigarette, which made no sense. Maybe you misspoke.

Most people I know who use pot VAPORIZE it, which eliminates tar and 95+% of all carcinogens. Personally I haven't smoked anything since 2005. Nasty and archaic method to consume anything. No need to demonize a non-toxic substance (THC) by conflating it with tar produced via combustion.
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My bad. I'll go back and clarify. Bad typo on my part. Weed contains up to 50x's tar. This is the most common form of consumption.
 
NukeDukem said:
Yet I just quoted you saying THC contains up to 50x more tar than a standard cigarette, which made no sense. Maybe you misspoke.

Most people I know who use pot VAPORIZE it, which eliminates tar and 95+% of all carcinogens. Personally I haven't smoked anything since 2005. Nasty and archaic method to consume anything. No need to demonize a non-toxic substance (THC) by conflating it with tar produced via combustion.
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*thumbs up* You have reduced your risk. Just remember that THC alters your brain on a long term use basis.
 
Mad[H]atter said:
Good thing early testing on monkeys always translates to repeatable safe results on humans so they can pre-hype a drug no where near it's final stages for use. :p

That never backfires countless times on AIDS drugs, Cancer drugs, etc. :p
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In my experience pretty much any animal, including non-wimp humans, can handle a fair amount of pain.

Unfortunately, those who cannot take a lot more than they need or should take. Do a few doctors grossly over-prescribe, sure but the number is very small and they should be dealt with harshly.

Not only does that put them at a higher risk of overdose, but when they actually have a significant painful event it is impossible to control their pain while they are conscious.

And if you look at actual statistics from reputable sources, the vast majority of the recent spike in overdoses is due to the addition of illegal Chinese made fentanyl being added to heroin. The addiction rate for real patients is less than 1-2% of those on long term narcotics, and far lower for those on short term post operative drugs. Vast quantities of prescription drugs end up getting resold for big bucks to those with an intent to abuse.

The more the government gets involved in anything, especially health care, the more fucked up it gets.
 
No such thing. If it relieves pain than it will be addicting. The addiction is the pain relief itself.
 
prime2515102 said:
I'll believe it when I see it. They claimed tramadol was less addictive and it turned out that not only is it just as addictive as other opioids, the addiction happens way faster. After a surgery I was on that crap for only eight days and withdrew from it like I had been on it for a year, and everybody I know that has been on it has had the same result.
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That was just as or more likely from Tramadol being so similar to Effexor, etc. Two withdrawals for the price of one.
 
I am sorry but i have been smoking weed for 25 years ( yeah i know dumbass ) and i am sorry to say i cant think of a single case where it have eased any pains i may have had / gotten.
I stopped that BS ( Cold turky ) 5-6 years ago, but sadly too late so that mixed with cigarette smoking and asbestos - epoxy - welding smoke and what not work related, have left me with lounges that cant even deal with my own walking speed.
Only right thing i did with drugs was i stopped drinking alcohol regularly before i was 25, thats highly irregular here in Denmark where kids drink more than anywhere else in the world.

Opiates are also popular here, but we have after all not reached American levels with this, but it is for sure clear that the former Viking Danes have become a bunch of pussies when it come to pain.
Though i must admit a visit to the dentist here, thats something you can walk or even drive from, even after jaw surgery like i had some years back, but those after the Dentist doped up Americans you see on youtube, thats like LOL and OMG rolled into one.
Not even the school dentist will dope you up like that, actually there at least when i was young all you could get was a little NOX gas.

O and as you might know we Danes have 100% public healthcare,,,, okay 98 % then cuz regular dental you have to pay yourself, so after my haw surgery i was sent home with no pain killers and worst of all no penicillin, so after a few days pus was oozing out of my jaw, and i can assure you that stuff dont smell or taste good.

Back OT, its good for the druggies that there are plenty of alternatives on the market.
 
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