You will basically want something with 64 PCIE 3.0 Lanes or 16 for each card 8 if you have to, so pretty much a 2011 socket system either x79 (Ivy-E0) or x99. You will probably need a XL-ATX or bigger board for fitting the cards too
The problem with the Maximus VI Extreme is that it will run x16, x8 , x8 , x8 so you may get performance losses (if so tiny) running in that mode