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Good idea! I'm hoping to build a new system in a few weeks and was thinking the same thing. You got any pics? Would like to see how it looks.I can add my ditto on the Z170 boards. I suspect the X99 boards are similar for support.
I've recently put a 950 Pro M.2 on my Maximus viii hero and had little problem getting it to work as my boot drive.
My advice to you:
Choose a board that has at least one native full length m.2 slot on the mboard and plop the latest bios you can get on it.
NVMe drives run way faster than normal sata ssds and they get damned hot! They will throttle back when they do. Think about getting a set of ramsinks to put on it. I used a set of 4 copper Enzotech BMR-C1 ramsinks on mine and have not regretted it in the least.
Good luck!
Good idea! I'm hoping to build a new system in a few weeks and was thinking the same thing. You got any pics? Would like to see how it looks.