There's not really any need for advice unless you've never played an RPG before. Fallout 3 and NV are pretty typical when it comes to the RPG elements; the exploration and questing are what make the games great. Exploring the D.C. wasteland and the Mojave wasteland is just awesome. They level of detail that they put into everything makes it seem like you're actually there being hunted by mutants, raiders, and scorpions.
My only real advice is just to explore the hell out of the map. Some of the most fun that I've had in FO 3 and NV has just been exploring and finding all of the stuff that they've hidden, looking at how the US might look after a nuke, and doing random quests.
My only real advice is just to explore the hell out of the map. Some of the most fun that I've had in FO 3 and NV has just been exploring and finding all of the stuff that they've hidden, looking at how the US might look after a nuke, and doing random quests.